EchoMRI Logo Body Composition Analysis
Rat Body Composition Human Body Composition Triglyceride Molecule Bird Body Composition Fruit Fly Body Composition Bat Body Composition Dog Body Composition Marmoset Body Composition Linolenic Acid Molecule Cat Body Composition Fish Body Composition
 
 
EchoMRI™ Body Composition Analyzer for Live Mice and Organs Live Mice and Organs
EchoMRI™ Body Composition Analyzer for Live Rats, Mice, Organs Live Rats, Mice, and Organs
3 in 1 EchoMRI™ Full View Body Composition Analysis for Live Mice, Organs, Biopsy 3-in-1 for Live Mice, Organs, and Biopsies
4 in 1 EchoMRI™ Body Composition Analyzer for Rats, Mice, Organs, Biopsy 4-in-1 for Live Rats and Mice, Organs and Biopsies
EchoMRI Body Composition Analyzer for Humans Humans: Adult, Child, Infant
 
Custom Built Systems
Hitachi Aloka Systems
LaTheta Micro-CT Scanner LCT-200 LaTheta Micro-CT

Questions & Answers


Most Asked | Configurations | Scan Procedure

Most Asked

How simple is it to use an EchoMRI™ device?
The EchoMRI™ systems are exceedingly easy to operate and maintain. A one hour training is sufficient for individuals without prior knowledge. Scan results are shown on the monitor and can be optionally extracted to plain ASCII, Excel, and Access files. The device is a stand-alone unit, it uses standard power sources, and it is completely safe to run.
How do the EchoMRI™ systems measure fat, lean, free water, and total water?
NMR instruments for composition analysis create contrast between soft tissues by taking advantage of the differences in relaxation times of the hydrogen proton spins in different environments. Radio pulses cause proton spins to precess and emit radio signals which are then received and analysed. The amplitude, duration, and spatial distribution of these signals are related to properties of the material scanned. The high contrast between fat, lean, and free water is further enhanced by application of specially composed radio pulse sequences.

Enquire about methods of measurements.

Does EchoMRI offer warranty on its products?
Our installation and training package includes a complete 1 year warranty, covering parts, labor, travel expenses, and applicable software upgrades. In addition, we try to visit a customer once or twice during the warranty period for a checkup. Extended warranties are also available.

Enquire about warranty options.

What size of animals can be scanned?
For small animals, organs and samples, our currently standard mass limits per holder are
  • 0.3g for small tissue samples (EchoMRI-4in1™, EchoMRI-3in1™),
  • 10g and 25g for organs, tissue samples, and very small animals (EchoMRI-Combo™/Compound, EchoMRI-4in1™, EchoMRI-3in1™),
  • 100g, 130g, and 200g for mice-size animals (EchoMRI-Combo™, EchoMRI-4in1™, EchoMRI-3in1™, EchoMRI-Mice™ EchoMRI-Birds™),
  • 300g, 500g, 700g, 900g, and 1100g for rat-size animals (EchoMRI-Combo™, EchoMRI-4in1™).

  • For humans and larger animals, our current standard mass limits per cradle are
  • 12kg for infants,
  • 80kg for children,
  • 250 kg for grown humans.
  • Enquire about custom-built sizes and specifications.

    What are the benefits of EchoMRI™ systems?

    No anesthesia or restraints are needed

    The fact that the animals can be scanned alive, awake, and unrestrained makes the measurements much more comfortable for both the animals and their handlers. An important benefit from this is that animals can be scanned as frequently as needed without undue stress or other effects on their health and well-being.

    Short scan duration

    In most typical cases, the scan can be completed in less than a minute if water is not included or a minute and a half if water is measured too.

    Unsurpassed precision

    The repeatability of measurement results is superior to any alternative methods that have been compared with EchoMRI™ so far.

    Adaptability

    Besides customized hardware, there is also the option of customized calibration of measurements for various types of animals and substances (see adaptability example).

    Enquire about other types of animals or substances.


    Most Asked | Configurations | Scan Procedure

    EchoMRI™ Scan Procedure

    How is an animal scanned?
    To be measured, an animal is placed in a specially sized, clear plastic holder without sedation or anesthesia. The holder is then inserted into a tubular space in the side of the EchoMRI™ system. The researcher then either presses a key on the keyboard or clicks a button on the LCD screen, and the scan starts.
    Can the animals move in the holders?
    Animals are scanned without anesthesia, sedation, or restraint and so are free to move in the holders. It is best to use holders of the smallest volume that can hold the animal, to restrict its movement and so reduce the measurement errors caused by motion.
    What are Fat, Lean, Free Water, and Total Water as measured by EchoMRI™ systems?
    Fat is the mass of all the fat molecules in the body expressed as equivalent weight of canola oil.

    Lean is a muscle tissue mass equivalent of all the body parts containing water, excluding fat, bone minerals, and such substances which do not contribute to the NMR signal, such as hair, claws, etc.

    Contributions to Free Water come mostly from the bladder. In experiments, for a limited time, water can be detected after it is injected into abdominal cavity of an animal, until it gets absorbed.

    Total Water includes both the Free Water and the water contained in Lean, that is all the water in the body. For normal animals, the hydration ratio (Total Water - Free Water) / Lean is typically within a few percent of 80%.

    What organs are considered to be lean mass?
    All organs contribute to lean mass.
    How the weight of an animal compares with the sum of the measured components.
    The general formula is

    (Weight) = (Lean) + (Fat) + (Free Water) + (Undetectable substances) + (Systematic Errors)

    where the undetectable substances such as bone mineral content, claws, hair, etc do not contribute to the NMR signal detected by the system.

    Why the sum of Fat, Lean, and Total Water is larger than the weight of an animal scanned?
    Most of the Total Water is already included in Lean and so counted twice in the sum of Fat, Lean, and Total Water.
    Why is canola oil used to conduct a system test? Can other fat be used as a test sample?
    From our experience with testing many animals and comparing NMR results with chemical analysis, we found that typically the NMR signal from fat in mice and rats can be well represented by the NMR signal from the same amount of canola oil.

    Using other fat for test sample would require customized software modifications.

    Enquire about customized software modifications.

    How the scan results depend on the entry in the Weight column?
    Whatever is entered or not in the Weight column, or in any column a user can access, plays no role in the measurements.
    What is the difference between measuring body composition by EchoMRI™ in a mouse and in a human (or in animals of substantially different sizes)?
    The methodology is exactly the same for all our systems, regardless of subject size. The hardware needs to be different for different sizes, including the optimal choice of magnetic field strength and of the nature of the magnets, permanent or electric.


    Most Asked | Configurations | Scan Procedure

    EchoMRI™ Systems' Configurations

    What are the physical dimensions and weight of EchoMRI™ equipment?
    EchoMRI™ device Part Dimensions
    Combo, Mice 24"W x 28"D x 58"H / 61cm x 71cm x 147cm
    4-in-1 48"W x 28"D x 52"H / 121cm x 71cm x 132cm
    3-in-1 24"W x 28"D x 52"H / 61cm x 71cm x 132cm
    Birds Computer Box 30"W x 23"D x 30"H / 76cm x 59cm x 76cm
    Magnet Box 24"W x 28"D x 33"H / 61cm x 71cm x 84cm
    AH, AH/Small Rack 24"W x 28"D x 58"H / 61cm x 71cm x 147cm
    Magnet Box 57"W x 144"D x 60"H / 145cm x 366cm x 152.5cm
    Infants 24"W x 77"D x 80"H / 61cm x 196cm x 203cm
    What power supply is needed? How much heat is generated by EchoMRI™ systems?
    EchoMRI™ systems for small animals power consumption is at most 500 W (1706 Btu/h).
    EchoMRI™ systems for humans power consumption is at most 2200 W (7507 Btu/h).

    One 110/220 VAC, 50/60 Hz outlet is required. The device is compatible with international standards required in America, Europe and Asia.

    EchoMRI™ systems for small animals have permanent magnets which generate no heat. EchoMRI™ systems for humans have electromagnets which generate heat similar to that of a computer workstation. The most heat generated by a component other than the magnet comes from the digital electronics, about as much as generated by a common personal computer.

    In a normal laboratory environment, no special air conditioning or environmental settings are required.

    What is the magnetic field in the vicinity of the EchoMRI™ system? Is any special shielding required?
    No special shielding is required. In systems for humans and animal systems with vertical gantry, the 5-gauss field is fully contained within the enclosure. In small animal systems with horizontal gantry, 5-gauss field is contained within the enclosure except for two hemispherical volumes of 9” radius at the opposite edges of the horizontal gantry.
    Can we move an EchoMRI™ system for small animals to another room or floor?
    Yes, it has casters for easy relocation.
    We recommend that after the relocation you perform our standard post-installation tests and send us the results for quality assurance.

    Enquire about post-installation testing procedures.

    May I lease or rent an EchoMRI™ system for animals?


    Most Asked | Configurations | Scan Procedure

    Collapse Expand